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If the role of aldolase in ATP production is important for the regulation of FA number and cell size, depletion of other glycolytic enzymes should phenocopy loss of aldolase

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Sobral et al., 2019)

CircRNA expression profiles of vitiligo patients before and after systemic glucocorticoids treatment were significantly different, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways revealed that the down-regulated differential circRNAs were predominantly enriched in ferroptosis regulatory pathways

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Think of skin differentiation like this: your skin cells are born at the bottom and slowly travel up to the surface as they "grow up"