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Environ Toxicol Pharmacol 51 : 3037

For example, as discussed above, we assume that normally 10% per hour of the cysteine, glycine, and glutamate in the blood is taken up by other cells and that an additional 25% of cysteine in the blood is lost by conversion to cystine

Graziani N S, Carreras H and Wannaz E 2019 Atmospheric levels of BPA associated with particulate matter in an urban environment

Neurosci Lett 10(12):171174 Sonnewald U, Westergaard N, Schousboe A, Svendsen JS, Unsgard G, Petersen SB (1993) Direct demonstration by [13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons

Conversely, when the copper chelator bathocuproine disulfate (BCS) was applied to cultures to reduce intracellular copper prior to exposure glutamate/glycine, neuronal death was increased (Schlief et al., 2006)

In the REDEFINE trials both components step up together about once a month so the gut adapts