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When it was recognized that pellagra, a condition marked by diarrhea, dermatitis, dementia, and mortality, could be treated with foods containing NAD+ precursors, particularly vitamin B3, the clinical significance of maintaining NAD+ levels was established in the early 1900s (9). Notably, the skin does not flush with NAD+ injection, in contrast to vitamin B3 (niacin) intake, which also causes this negative effect (10). Low NAD+ levels have recently been associated with a variety of age-related ailments and diseases linked to increased oxidative/free radical damage, including diabetes, heart disease, vascular dysfunction, ischemic brain injury, Alzheimers disease, and vision loss (8, 11-17)

How To Use: For Healthcare Professionals: Administer via intramuscular or subcutaneous injection as directed by a physician

In our naturopathic clinic in Phoenix we initially see improvement in energy and mental states

Lower Abdomen: Effective for Subcutaneous Injections For individuals opting for subcutaneous B12 injections, the lower abdomen is one of the most effective sites

These include: Leucine: Central to muscle growth by catalyzing protein synthesis

If you're tired after B12 shot or experiencing worsening symptoms, there are several steps you can take to mitigate these effects and optimize the benefits of B12 supplementation