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Oral contraceptives, which interfere with B6 metabolism, have also been associated with low levels

a neurotransmitter deficiency state including the elevation of GABA (gamma-amino-benzoic acid), PEA (phenyl-ethyl-amine), and histamine, and more generally any abnormal alteration of excitatory or inhibitory neurotransmitters that result in a disease state

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Although clinical trials are limited, the evidence suggests that B12 injections at a dose of at least 500 g three times per week for 2 weeks are effective in relieving chronic low back pain

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However, HIF activates the transcription of SOCS3 which inhibits JAK/STAT3 signaling and thus inhibits the expression of adiponectin (Fig