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The systemic iron pool builds up mainly from duodenal enterocytes absorbing iron, hepatocytes, and macrophages of the reticuloendothelial system recycling senescent erythrocytes, with ferroportin (FPN1) as the only way out to exit these cells

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The discovery of the existence of supercomplexes in the respiratory chain [114] and the recognition of their function [115] led to the modification of the fluid model to the plasticity model, which adds to the fluid model a new view of the structural and functional complexity in the transfer of electrons in the mitochondrial ETS, as well as the function of the CoQ 10 pool in the IMM [111,116,117]

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