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Concerns about potential teratogenicity (birth defects), effects on pregnancy, or safety during lactation have not been adequately studied, so use during pregnancy or breastfeeding is not recommended absent compelling indication and appropriate medical supervision

The study aims to clarify the structural and functional aspects of how this antivitamin interacts with CblC, which is crucial for converting vitamin B12 into its active forms

U01 DK048489 by providing funding during DPP and DPPOS to the clinical centres and the coordinating centre for the design and conduct of the study, and collection, management, analysis and interpretation of the data

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DDR pathway activation phosphorylates and activates p53, which subsequently induces the expression of p21 23