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Nevertheless, NBS can facilitate early treatment and significantly reduce the symptom onset in mut patients, and the lower metabolic indicator levels before treatment in the NBS group of mut-MMA patients indicated that the early diagnosis due to NBS can effectively reduce the occurrence of damaging or even fatal acute metabolic derangement at initial presentation

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In this article, we aim to review the management of HE, starting with the efficacy and limitations of traditional agents with a focus on the evidence supporting newer therapies in HE (Table 1)

The reason for the greater increase in our study is presumably that excessive L-carnitine is excreted into the urine in mice, while in the medaka model, the compound was dissolved in the water in the tank, which allowed medakas to maintain higher L-carnitine levels