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These ubiquitination events contribute to mitochondrial dysfunction, oxidative stress, inflammation, and fibrosis
Redox-control of chlorophyll biosynthesis mainly depends on thioredoxins
10.1038/ng1511
It is composed of three amino acids: cysteine, glutamic acid, and glycine
Selenocysteine, which is not one of the 20 proteinogenic amino acids, is involved in the synthesis of GPX4
These results suggest that a decline in GPX1 activity in the mitochondria may lead to increased levels of ROS, which in turn results in mitochondrial dysfunction, leading to cochlear cell loss and associated hearing loss
