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An initial dosedependent study conducted by Koene et al

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Once SCFAs are absorbed into the bloodstream through the walls of the large intestine by a process known as passive diffusion, they are transported to the liver via the portal vein and then distributed to several tissues, where they can interact with specific receptors such as G protein-coupled receptors (GPRs) and influence gene expression, cellular metabolism and immune response (66, 76)

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60 In particular, in untreated HIV-inflicted subjects, sCD14 was independently associated with TMAO