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Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis

Animal models are useful for preclinical evaluation of therapeutic interventions, bridging the gap between in vitro assays and human clinical trials [25, 61, 62]

A review in Proceedings of the National Academy of Sciences noted that "multiple large case-control studies have reported positive associations between high circulating levels of IGF-I and risk for different types of cancer," including breast, colorectal, and prostate cancers

AgelessRX has offered off-label rapamycin among its longevity therapies

Although many questions remain (Table 1), the explosion of knowledge in the last 15 years has made beta-alanine one of a handful of supplements with ergogenic potential when utilized with an optimal dosing protocol in sustained high-intensity events