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Safe upper levels for vitamins and minerals

Essential role for autophagy in life span extension
Groff D, Sun A, Ssentongo AE, Ba DM, Parsons N, Poudel GR, et al

15 We hypothesize that additional vasoconstriction through caffeine's antagonism of adenosine receptors, inhibition of phosphodiesterase enzymes, and other molecular effects on endothelial and vascular smooth muscle cells may have contributed to a local ischemic event

The loss of redox homeostatic balance in the brain in the presence of increased ROS or reduced GSH and similar antioxidant molecules may suggest a pro-inflammatory aetiology in MDD

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