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22,56,57 Cardiovascular diseases and related risk factors (e.g., hypertension, atherosclerosis) impair blood flow to peripheral nerves, worsening neuropathic symptoms

Obesity and insulin resistance

It is diagnosed according to the Canadian consensus criteria, at least 6 months after onset when the following symptoms are present: fatigue, post-exertional malaise with a recovery period of at least 24 h, sleep dysfunction, pain, at least two neurological/neurocognitive symptoms and at least two symptoms involving the autonomic, neuroendocrine or immune system [19]

Association between plasma trimethylamine N-oxide levels and type 2 diabetes: a case control study

Symptoms can include difficulty breathing, hives, and swelling of the face, lips, tongue, or throat [12]

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