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The samples were stored at 80C until being packed in dry ice and sent to Maiwei Metabolomics (Wuhan, China) for analysis

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Study limitations Oral NAC is associated with gastrointestinal discomfort, nausea, and diarrhea, but these symptoms are generally mild and occur at similar rates in placebo groups, indicating that NAC is well-tolerated and safe for chronic use [108]

Furthermore, GPX3 plays a crucial role in the growth regulation and differentiation of various malignant tumor cells, exhibiting dual roles in different tumors

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