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Accessed 3/10/2016

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Appl Environ Microbiol 89:e0063000623 Whelan S, Goldman N (2001) A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach

As in the previous model, also in this one an increase in the number of hypoxic cells has been found suggesting again a link between post treatment development of hypoxia and escape from drugs targeting the new vessels [48,49]