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The cortex and the hippocampus are usually spared after one month of hypoperfusion but changes in these areas can be detected after prolonged (several months) hypoperfusion (376)

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Ionic manganese (Mn 2+ ) is a widely studied cation and a known environmental risk factor for PD
The brain has the capacity to convert the glutathione S -conjugate and cysteinyl S -conjugate of dopamine to the corresponding mercapturate (Shen et al., 1996)
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doi: 10.1039/C5FO00497G