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Synergistic or antagonistic interactions between compounds can alter their individual pharmacokinetics, necessitating careful adjustments and extensive preliminary research for each compound

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This AMP was also reported to trigger neutrophils to produce ectosomes (antimicrobial microvesicles), demonstrating the potential therapeutic potential of cathelicidin LL-37

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Furthermore, AMPs frequently demonstrate suboptimal pharmacokinetic properties, such as rapid systemic clearance and limited bioavailability, necessitating the development of advanced delivery systems to enhance their efficacy [181]

[DOI] [PMC free article] [PubMed] [Google Scholar] Marx D., Bartsch T., Wohnhas R., Zwisler W