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DEC-2012/07/B/NZ4/00197/from the Polish National Science Centre (NCN)

Similar to the results previously shown, Klotho contributed to PI3K/AKT/FOXO3-related increase in MnSOD expression in Tac-injured HK-2 cells and mouse kidneys or rat renal IRI models 69,72

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[DOI] [PubMed] [Google Scholar] 52.Dembinska-Kiec A, Mykkanen O, Kiec-Wilk B, Mykkanen H

Excessive pyroptosis leads to rapid rupture of the plasma membrane and the excessive release of proinflammatory cytokines and chemokines, which results in neuroinflammation that triggers a cascade of secondary injuries culminating in neuronal death

The Quercetin Paradox This duality in quercetinand its potential to be metabolized down one of two very different pathwaysis known as the "quercetin paradox." Because quercetin can oxidize so easily, forming pro-oxidant, toxic metabolites, special care must be given to how quercetin-containing products are formulated