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The "rapid reversal" group (approximately 10-15% of users) experiences concerning quick benefit loss within weeks of discontinuation, typically involving users who applied very high concentrations creating dependency-like patterns, possessed severe underlying skin conditions requiring ongoing treatment, experienced significant lifestyle or environmental stressors overwhelming skin resilience, discontinued abruptly without tapering from high-dose protocols, or had unrealistic perception inflation during treatment leading to exaggerated reversal perception

It also modulates the Nitric Oxide (NO) system, providing a potent cytoprotective effect on the endothelium and gastrointestinal mucosal lining

Shou et al., 2005

Subcutaneous Self Injections: Subcutaneous Self Injections Are there any side effects

doi:10.1179/1476830515Y.0000000006

The study was based on an analysis of medical records in Scotland