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This review systematically synthesizes the immunometabolic regulatory mechanisms of PANoptosis in diabetes and its complications, clarifies its cell-specific roles in -cells, immune cells, and vascular tissues, and evaluates therapeutic strategies targeting the metabolic-immune crosstalk axis and core PANoptotic components, providing new theoretical basis and potential targets for precision intervention in diabetes and its complications.

Methods We developed a novel approach to identify anticipated events for a hypothetical randomized, double-blind, controlled trial in subjects with bipolar disorder using the adverse events reported in the placebo arm of trials from the ClinicalTrials.gov database