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In vitro study found that topiramate increased MDA, NO and ROS production in astrocytes, showing a dose-dependent negative effect (Pavone and Cardile, 2003)
[DOI] [PubMed] [Google Scholar] 341.Nagareddy P.R., Kraakman M., Masters S.L., Stirzaker R.A., Gorman D.J., Grant R.W., Dragoljevic D., Hong E.S., Abdel-Latif A., Smyth S.S., et al
Autophagy 13 , 464472 (2017)
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These individuals were thought to harbor an abnormality in the enzyme, transketolase
