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According to the manufacturer, Rx B12 is best given with food or around a meal

2004, Ed Masson, Barcelona Hvas AM, Juul S, Nexo E, Ellegaard J: Vitamin B-12 treatment has limited effect on health-related quality of life among individuals with elevated plasma methylmalonic acid: a randomized placebo-controlled study

For example, Fleischer and colleagues found CP enlargement, increased numbers of CP macrophages and T cells in the CP after two weeks of cuprizone treatment [261]