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Its likely that a combination of factors is at play. MS-specific studies, including one published in February 2026 on PubMed Central , say that low sun exposure, Vitamin D deficiency, using tobacco, lack of exercise, and obesity are some of the leading causes of MS onset

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145 A complicating factor in determining metformin-induced deficiencies is that there are large vitamin B12 stores in the liver and these can take up to five years to manifest as a deficiency

In regards to loss of weight, there is no documented outcome that supports vitamin B12 shots or injections promoting weight loss

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Key Takeaways: Pale or red skin might signal a lack of B12 Some might notice dryness, cracking, or slower healing of wounds Tingling or numbness in the face can be linked to nerve trouble Tests reveal whats happening better than just guessing Treating it soon can get your skin back to normal What Low B12 Does to Your Skin Vitamin B12 plays a key role in keeping skin cells healthy, supporting nerve health, and maintaining good blood flow