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At that concentration, a 300 mcg dose is about 0.18 mL (18 units on a U-100 syringe) and a 500 mcg dose is about 0.30 mL (30 units)

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doi:10.1001/jama.1938.02790090004002

A C20 fatty diacid moiety attached at position 20 extends its half-life dramatically, allowing once-weekly dosing instead of the multiple daily injections that earlier peptides required

SOPs existed on paper, but the evidence shows they were not being implemented in practice