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IGF-1 expression has been shown to be activated by estrogens whereas breast tumors with BRCA1 mutations demonstrate elevated IGF-1 levels

[DOI] [PMC free article] [PubMed] [Google Scholar] 410.Wiser J., Alexis N.E., Jiang Q., Wu W., Robinette C., Roubey R., Peden D.B

2015 Apr;61(4):347-9 [PubMed] 27257155 Mo L, Liang D, Madden A, Aung AK

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177 Peripheral inflammation is associated with the activation of immune cells, including T cells, macrophages, and monocytes, which can breach the BBB due to their increased permeability in this disease state

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