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Acknowledgements The work was supported by National Natural Science Foundation of China (82470182, 62205094), Basic Scientific Research Funds of Department of Education of Zhejiang Province (KYYB202213), Excellent research start-up fund of Zhejiang Provincial People's Hospital (ZRY2021A002), Adjunct Talent Fund of Zhejiang Provincial People's Hospital, 2024 General Scientific Research Project of Zhejiang Provincial Department of Education - Special Project for Reform of Professional Degree Graduate Training Mode (No

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