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Proteomic Profiling of 112 Proteins in Chronic Myeloid Leukemia Patient Samples Using Reverse Phase Proteins Arrays (RPPA) Reveals Distinct Protein Expression Signatures Associated with Advanced Phase Disease and the CD34+ Compartment

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tesamorelin if visceral fat is the primary target Starting dose 50% of standard adult dose, titrated up over 46 weeks based on IGF-1 response and side effect tolerance Administration subcutaneous injection, typically at bedtime to align with natural GH pulsatility 8-week reassessment IGF-1, fasting glucose, HbA1c, symptom review, body composition measurement Ongoing monitoring every 812 weeks