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Alignment coordinates were converted to BED format using BEDTools v.2.17 and H3K27ac peak calling was performed using SICER v1.1 60

PPDB, based on EU and UK regulatory guidelines 15,16 , introduced a 3-level (ternary) highly toxic/moderately toxic/non-toxic labels, with thresholds 1 g/org and 100 g/org

If HPLC and MS results conflict, the batch should not be treated as verified until the discrepancy is investigated

S8C): Blood vessels were not visible in images stained for elastin