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Description
The most common cardiovascular (CV) manifestations in patients with type 2 diabetes are heart failure (HF), stable angina, nonfatal myocardial infarction (MI), peripheral arterial disease and ischemic stroke [2,3,4] which accounts for 60% of their deaths [5]
Pancreatitis Acute pancreatitis has occurred in patients treated with GLP-1 agonists, including tirzepatide
doi:10.1056/NEJMoa2032183 Cava E, Yeat NC, Mittendorfer B
The peptide binds by a two-domain mechanism, with its C-terminus held by the extracellular domain while its N-terminus inserts into the transmembrane bundle to switch the receptor on
As evidence grows, NPs must align use with individual risk profiles, comorbidities, and treatment goals
Concepcion JQ et al (2021): Metformin for pediatric obesity and insulin resistance: a retrospective study within an integrated health care system
