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[DOI] [PMC free article] [PubMed] [Google Scholar] 162.Grant C., Rahman F., Piekarz R., Peer C., Frye R., Robey R.W., Gardner E.R., Figg W.D., Bates S.E

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RNA extraction and quantitative real-time PCR analysis All the tissues were harvested at indicated time points after APAP injection

121 While degenerative IVDs can secrete many inflammatory and pain mediators, including TNF-, IL-1, IL-6, IL-8, substance P, and prostaglandin E2, these factors not only reduce proteoglycan and collagen synthesis but also stimulate nerve fiber ingrowth and induce pain

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