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Nicotine exposure during adolescence induces a depression-like state in adulthood

Oxidative stress creates inflammation at a cellular level

Recent studies have also indicated that cellular metabolic reprogramming, mitochondrial dysfunction, endoplasmic reticulum stress, and regulated cell death pathways like ferroptosis and pyroptosis are not mere consequences but are central drivers of ALI progression, modulating apoptotic and autophagic pathways (Wang et al., 2025

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Disruption of circadian rhythms contributes to obesity, metabolic disease and cancer, yet how the clock maintains metabolic homeostasis remains limited