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Jamwal S, Gautam A, Elsworth J, et al

In addition to their central role in supporting a large network of antioxidant defenses, GSH and TRX have a variety of biological functions such as regulation of enzymatic activity, receptors, transcription factors, and ultimately redox-sensitive signal transduction, short-term storage of cysteine, protein structure, cell growth, proliferation, and programmed cell death [45]

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However, this response was not observed in M1 macrophages, which were able to sustain cell survival and their antimicrobial functions

Clinical and preclinical trials are currently in progress to explore the bioactive characteristics of these compounds (Farag et al ., 2020)