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Jamwal S, Gautam A, Elsworth J, et al

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In addition to their central role in supporting a large network of antioxidant defenses, GSH and TRX have a variety of biological functions such as regulation of enzymatic activity, receptors, transcription factors, and ultimately redox-sensitive signal transduction, short-term storage of cysteine, protein structure, cell growth, proliferation, and programmed cell death [45]

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However, this response was not observed in M1 macrophages, which were able to sustain cell survival and their antimicrobial functions

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Clinical and preclinical trials are currently in progress to explore the bioactive characteristics of these compounds (Farag et al ., 2020)

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