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The animal model conducted by (Ritesh et al., 2015) used CCl4 to induce oxidative stress to determine its effect on the brain (Ritesh et al., 2015)

doi: 10.2165/00126839-200506060-00004

10.3390/sports9090127 139 PopatB.JonesA

Statistical analysis All experiments were independently performed in at least triplicate

Long-term metformin therapy and vitamin B 12 deficiency: an association to bear in mind

That's why it's considered risky and why it isn't an approved treatment