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The extracellular environment mainly contains Cu 2+ , while the intracellular environment mainly contains Cu + (19, 20)

Zhang JC, Yao W, Hashimoto K (2016) Brain-derived neurotrophic factor (BDNF)-TrkB signaling in inflammation-related depression and potential therapeutic targets

ROS mutate genes involved in various metabolic pathways throughout the body and prevent the detoxification and excretion of toxic waste

JCI insight, 2(2), e90427
For example, tumor necrosis factor receptor 2 (TNFR2)-mediated costimulatory signals promote a glycolytic switch in human thymus-derived Treg cells [159] (Fig
