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This includes downregulation of mitochondrial OXPHOS, decreased expression of mitochondrial complexes I-V, and dysfunction of respiratory enzymes in AD brains and models [101]

Zobel-Thropp et al., 2018

Platelets are important for blood to clot, and not enough can cause bleeding problems
76 p53 suppresses tumor through regulating its target gene, glutamine synthase 2 (GLS2), which exerts antioxidant defense function

In order to generate a large sample population and exclude any possible bias, like the Hawthorne study shows, this retrospective study design was chosen to resemble daily clinical practice routines 51

10.1016/j.jacc.2017.05.019 J Am Coll Cardiol
