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Based on previous reports and preliminary experiments conducted in our lab, the treatments tested were IGF-I at 100 ngmL 1 (Wasielak et al., 1 ) (Yeste et al., In experiment 1, cumulusoocyte complexes (COCs) obtained from pre-pubertal gilts ovary were selected and matured in vitro in conventional IVM medium (control) or in the same medium supplemented with 100 ngmL 1 IGF-I

**Validated by a 2025 independent laboratory perception study

Glutathione helps inhibit tyrosinase, the enzyme responsible for melanin production, supporting gradual skin brightening and tone correction

The nanozyme activities could be tuned simply by varying the reaction pH

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One of the stool samples, contained a previously unknown strain of bacteria, which was named Lactobacillus fermentum ME-3