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The proteomics big challenge for biomarkers and new drug-targets discovery

The human digestive system quickly breaks down water soluble compounds such as glutathione, so eating glutathione rich foods or taking oral glutathione supplements may not produce any clinically significant results

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Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines

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It has also been shown that ferroptosis causes marked morphological changes to mitochondria, such as shrinking, cristae disappearance, disruption of OMM, and increased bilayer membrane density [234, 235]