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The how peptides work article provides the biological context for understanding these interactions

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[106] [107] [108] [109] The serotonin releasing effects of tramadol could be blocked by sufficiently high concentrations of the serotonin reuptake inhibitor 6-nitroquipazine, which is in accordance with other serotonin releasing agents such as fenfluramine and MDMA

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The process of freezing and thawing creates ice crystals that can physically damage the peptide chains, leading to significant potency loss

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