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But when the same receptor gets hit with the same signal nonstop, a chain of events unfolds: The cell marks the receptor with a chemical tag (phosphorylation) A protein called beta-arrestin grabs the tagged receptor and shuts down further signaling The cell pulls the receptor inside (internalization) Some receptors get recycled and put back on the surface

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Comparison of oral with rectal mesalazine in the treatment of ulcerative proctitis

pharmacological modulation of HSP70 dependent mechanisms of endogenous neuroprotection

Petta S, Camma C, Scazzone C, et al

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