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Bolam, J

doi: 10.1007/s00213-011-2619-3

Vitamin B-12 injections may cause redness, bruising, and tenderness at the injection site

The authors concluded that prolonged increases in vein wall tension are associated with overexpression of HIF-1 and HIF-2 , increased MMP-2 and MMP-9 expression, and reduced venous contraction in rat IVC

Moreover, crocin decreased M1 macrophages polarization ( Supplementary Figure 3A )

414,415 Notably, cisplatin-mediated tumor cell ferroptosis can promote the anti-tumor efficacy of ICI therapy by reprogramming TME characterized by the N1 neutrophil polarization and increased T-cell infiltration and Th1 differentiation in NSCLC