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When Nrf2 responses are inadequate, lipid peroxides can trigger inflammation through the nuclear factor kappa B (NF-B) pathway ( NF-B functions as a principal modulator of inflammatory processes (Nowak and Relja, 2020)

Glutamate is then converted to -ketoglutarate (-KG) by mitochondrial glutamate dehydrogenase (GLUD) (Altman et al., 2016

Immunoblot assay Following extraction of genomic DNA, the samples were denatured at 100 C for 10 min, and 500 ng per well was spotted onto nitrocellulose membranes (Bio-Rad, Hercules, CA, USA) using a slot-blot apparatus (Omniphor, San Jose, CA, USA)

The reaction was carried out in a 384-well plate (PerkinElmer, 6007280) with DMSO at a final concentration of 1%

Glutathione is a powerful antioxidant that helps brighten skin by inhibiting the enzyme tyrosinase, which is responsible for melanin production

A Shimadzu LC20AD, Ultra Performance Liquid Chromatography (UPLC) system (Shimadzu Corporation, Kyoto, Japan) equipped with Shimadzu 8040 triple quadrupole (QqQ) mass analyzer (Shimadzu Corporation, Kyoto, Japan) with an electrospray ionization source (ESI) operated in the positive charge mode for the quantification of 2
