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Our own body can synthesize small amounts, provided that the precursors (two essential amino acids, lysine and methionine) and the required cofactors (vitamins C, B3, B6 and iron) are available

For example, markers of enhanced oxidative stress and diminished methylation ability, such as reduced S-adenosylmethionine/S-adenosylhomocysteine and GSH/GSSG ratios, have been detected in the plasma of autistic children [114,115,116]

In eukaryotes, TML is the product of lysosomal or proteasomal degradation of proteins such as calmodulin, myosin, actin, cytochrome c, and histones, which contain N -methylated lysine residues from post-translational modification (Strijbis et al., 2010)

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Maenner et al., 2023)