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To determine whether the Ee Extra Loop affects inhibitor potency, we deleted residues M149 to A159, which comprise the loop

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6 Tendon injury 6.1 Mechanosensitive calcium pathways and ROS generation in tendon injury Calcium ions (Ca 2+ ) are regulators of tendon cell signaling, acting as key second messengers that mediate processes such as cytoskeletal dynamics, ECM remodeling, oxidative balance, and apoptotic signaling ( via IP 3 and ryanodine receptors, while reuptake is governed by SERCA pumps

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The depletion of GSH and accumulation of GSSH increases oxidative muscle damage 2