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Erastin, as a small-molecule ferroptosis inducer, works by inhibiting the system Xc transporter-an amino acid antiporter responsible for exchanging extracellular cystine for intracellular glutamate (11)-leading to depletion of intracellular glutathione (GSH), indirectly inactivating glutathione peroxidase 4 (GPX4), and ultimately triggering ferroptosis (12)

Tarantino, G., Di Minno, M

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doi: 10.1016/S1474-4422(12)70295-8 12 Barnab-HeiderF.GritzC.SabelstrmH.TakebayashiH.PfriegerF

With intestinal disease (including bypass operations that may be performed to treat obesity), increased fecal loss of bile acids leads to decreased concentrations of both primary and secondary bile acids and, often, a decrease in cholesterol caused by increased need for bile acid synthesis

FTIR data were not available for this compound