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Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression

J Pharm Biomed Anal 138:109117 Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P (2018) Oxidative stress, aging, and diseases

LC conditions: Separation of ceramide species was performed on an Agilent 1200 series HPLC system (Agilent Technologies, Palo Alto, CA) using an Ascentis C18 column (5 cm 2.1 mm I.D., 3 m particle size, Supelco, Bellefonte, PA)

Antioxidantssuch as vitamins C and E, coenzyme Q 10 , and plant compounds called polyphenolscan help protect dogs by neutralizing these harmful molecules

The resulting transcriptional upregulation of BDNF supports synaptic differentiation, spine formation, and synaptic efficacy

All mice used in the present study were in a C57BL/6 background