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Introduction In the spectrum of fibrotic conditions, penile fibrosis is characterized by disproportionate accumulation of collagen components in the tunica albuginea, penile corpora cavernosa, and corpus spongiosum, termed as Peyronies disease (PD), corporal fibrosis, and urethral stricture respectively (Garaffa et al., 2013

doi:10.1002/lary.26607

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Inflammatory cytokines like TNF-alpha and IL-6 interfere with insulin signaling and promote fat accumulation