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Despite the substantial conformational dynamics when bound to AMY 3 R, Cagri maintains the bypass conformation across the motions, likely arising from the consistent TMD and linker interactions between RAMP3 and CTR that enable robust engagement of residues within the Cagri bypass motif

HNE can initiate p53-mediated apoptosis in RPE cells, while HHE can stimulate NF-B-associated inflammatory pathways and disrupt mitochondrial membrane permeability [294,295]

doi: 10.1080/09553000110104065

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The results (Tables 3S, and 4S) confirm the preservative properties of the product

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