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Furthermore, addressing the challenges of patient heterogeneity, drug resistance, and adverse effects will be critical for the successful translation of ferroptosis-targeted therapies into clinical practice

Studies revealed that by increasing the concentrations of the cytosolic cysteine, and thus glutathione of monocytes and macrophages using a synthetic form of cysteine called NAC, blocks H 2 O 2 mediated activation of NF-kB, and thus pro-inflammatory cytokines (tumor necrosis factors [TNF]-, interleukin [IL]-1 and IL-6) by this route

IVIg remains the only immunomodulatory therapy with proven benefit in SPS

10.1016/j.psj.2020.07.016 [DOI] [PMC free article] [PubMed] [Google Scholar] 8.Kakuda T

Although ROS play essential roles in the maintenance of basal cellular activities such as chondrocyte proliferation and matrix remodeling in cartilage, excessive oxidative stress causes detrimental events such as cellular senescence 36,121 , dedifferentiation 122 , and apoptosis 123