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These compounds can cause blood vessels to expand, leading to headaches

The titration schedule (increasing the dose every 4 weeks) is designed to be a long-term protocol

While the reaction of the therapeutic antibody seems relatively straightforward on the myeloma side (as MM cells are FcR-negative), more complex interactions occur with effector cells (FcR + ), where the antibody can engage both the Fab-binding site and one of the FcRs on the same cell ( Figure 3 ) (110)

Conversely, if thyroid dysfunction prompted the visit and pernicious anemia surfaces during workup, the thyroid condition sequences as principal diagnosis

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