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PubMed, Agostini, Deborah, et al

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When this happens, and additionally infection by SARS-CoV-2 downregulates ACE2 abundance on cell surfaces, as suggested by evidence from related coronaviruses [2], the result is the toxic overaccumulation of ANGII, exacerbated inflammation and, finally, acute respiratory distress syndrome and fulminant myocarditis (Figure 1)

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IFN, a group of signaling proteins produced and secreted by host cells in response to pathogen infection (96, 97), has been used in the treatment of hepatitis B virus infection (98100)

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function