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Nevertheless, the mechanisms of nicotine addiction remain only partially understood

AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin

JAAD Case Rep 2017;3:4779

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However, the study had limitations regarding sample size, geographical location, and exclusion of patients with diagnosed mood disorders, which could have influenced sleep patterns